PROLONGED SURVIVAL OF XENOGRAFTS DESPITE SENSITIZATION
نویسندگان
چکیده
منابع مشابه
Pretreatment of recipients (nude rat) with donor antigens leads to prolonged survival of hamster heart xenografts.
THE INITIAL barrier to successful organ xenotrans1. plantation in discordant species is hyperacute rejection (HAR) mediated by either natural (preformed) or induced antibodies. 1•2 Hamster cardiac xenografts are normally rejected by this mechanism within 3 days when transplanted into naive LEW or athymic (nude) rats,3 which in the latter is supposedly caused by a T-cell independent process. Thi...
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The aim of the present study was to explore the survival of pig-rhesus corneal xenografts following donor bone marrow transplantation (BMT). Wuzhishan pigs were used as donors and rhesus monkeys as recipients for corneal xenotransplantation. Twelve rhesus monkeys were divided into two groups. Group 1 received intravenous injection of cyclophospham...
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Treatment of C57BL/6 mice with one transfusion of BALB/c spleen cells and a brief course of anti-CD154 (anti-CD40 ligand) antibody permits BALB/c islet grafts to survive indefinitely and BALB/c skin grafts to survive for approximately 50 days without further intervention. We now report adaptation of this protocol to the transplantation of islet and skin xenografts. We observed prolonged surviva...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1977
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-197704000-00706